Executive Summary: REDUCING ENVIRONMENTAL CANCER RISK... What We Can Do Now - April 2010

Submitted by Norm Roulet on Wed, 05/19/2010 - 23:12.

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Below is the Executive Summary from the 2008–2009 Annual Report of the President’s Cancer Panel - REDUCING ENVIRONMENTAL CANCER RISK... What We Can Do Now - April 2010. This report is submitted to the President of the United States in fulfillment of the obligations of the President’s Cancer Panel.

Executive Summary

Despite overall decreases in incidence and mortality, cancer continues to shatter and steal the lives of Americans.  Approximately 41 percent of Americans will be diagnosed with cancer at some point in their lives, and about 21 percent will die from cancer.  The incidence of some cancers, including some most common among children, is increasing for unexplained reasons.

Public and governmental awareness of environmental influences on cancer risk and other health issues has increased substantially in recent years as scientific and health care communities, policymakers, and individuals strive to understand and ameliorate the causes and toll of human disease.  A growing body of research documents myriad established and suspected environmental factors linked to genetic, immune, and endocrine dysfunction that can lead to cancer and other diseases.

Between September 2008 and January 2009, the President’s Cancer Panel (the Panel) convened four meetings to assess the state of environmental cancer research, policy, and programs addressing known and potential effects of environmental exposures on cancer.  The Panel received testimony from 45 invited experts from academia, government, industry, the environmental and cancer advocacy communities, and the public.

This report summarizes the Panel’s findings and conclusions based on the testimony received and additional information gathering.  The Panel’s recommendations delineate concrete actions that governments; industry; the research, health care, and advocacy communities; and individuals can take to reduce cancer risk related to environmental contaminants, excess radiation, and other harmful exposures.

Key Issues for Reducing Environmental Cancer Risk

Issues impeding control of environmental cancer risks include those related to limited research on environmental influences on cancer; conflicting or inadequate exposure measurement, assessment, and classification; and ineffective regulation of environmental chemical and other hazardous exposures.

Environmental Cancer Research

Research on environmental causes of cancer has been limited by low priority and inadequate funding.  As a result, the cadre of environmental oncologists is relatively small, and both the consequences of cumulative lifetime exposure to known carcinogens and the interaction of specific environmental contaminants remain largely unstudied.  There is a lack of emphasis on environmental research as a route to primary cancer prevention, particularly compared with research emphases on genetic and molecular mechanisms in cancer.

Environmental Exposure Measurement, Methodologic, Assessment, and Classification Issues

Efforts to identify, quantify, and control environmental exposures that raise cancer risk, including both single agents and combinations of exposures, have been complicated by the use of different measures, exposure limits, assessment processes, and classification structures across agencies in the U.S. and among nations.  In addition, efforts have been compromised by a lack of effective measurement methods and tools; delay in adopting available newer technologies; inadequate computational models; and weak, flawed, or uncorroborated studies.

Some scientists maintain that current toxicity testing and exposure limit-setting methods fail to accurately represent the nature of human exposure to potentially harmful chemicals.  Current toxicity testing relies heavily on animal studies that utilize doses substantially higher than those likely to be encountered by humans.  These data—and the exposure limits extrapolated from them— fail to take into account harmful effects that may occur only at very low doses.  Further, chemicals typically are administered when laboratory animals are in their adolescence, a methodology that fails to assess the impact of in utero, childhood, and lifelong exposures.  In addition, agents are tested singly rather than in combination.

Regulation of Environmental Contaminants

The prevailing regulatory approach in the United States is reactionary rather than precautionary.  That is, instead of taking preventive action when uncertainty exists about the potential harm a chemical or other environmental contaminant may cause, a hazard must be incontrovertibly demonstrated before action to ameliorate it is initiated.  Moreover, instead of requiring industry or other proponents of specific chemicals, devices, or activities to prove their safety, the public bears the burden of proving that a given environmental exposure is harmful.  Only a few hundred of the more than 80,000 chemicals in use in the United States have been tested for safety.

U.S. regulation of environmental contaminants is rendered ineffective by five major problems: (1) inadequate funding and insufficient staffing, (2) fragmented and overlapping authorities coupled with uneven and decentralized enforcement, (3) excessive regulatory complexity, (4) weak laws and
regulations, and (5) undue industry influence.  Too often, these factors, either singly or in combination, result in agency dysfunction and a lack of will to identify and remove hazards.encountered by humans.

Sources and Types of Environmental Contaminants

The line between occupational and environmental contaminants is fine and often difficult to demarcate. Many known or suspected carcinogens first identified through studies of industrial and agricultural occupational exposures have since found their way into soil, air, water, and numerous consumer products.  People from disadvantaged populations are more likely to be employed in occupations with higher levels of exposure (e.g., mining, construction, manufacturing, agriculture, certain service sector occupations) and to live in more highly contaminated communities.  The reality of this unequal burden is not just a health issue, but an issue of environmental justice.

While all Americans now carry many foreign chemicals in their bodies, women often have higher levels of many toxic and hormone-disrupting substances than do men.  Some of these chemicals have been found in maternal blood, placental tissue, and breast milk samples from pregnant women and mothers who recently gave birth.  Thus, chemical contaminants are being passed on to the next generation, both prenatally and during breastfeeding.  Some chemicals indirectly increase cancer risk by contributing to immune and endocrine dysfunction that can influence the effect of carcinogens.

Children of all ages are considerably more vulnerable than adults to increased cancer risk and other adverse effects from virtually all harmful environmental exposures.  In addition, some toxics have adverse effects not only on those exposed directly (including in utero), but on the offspring of exposed individuals.

Exposure to Contaminants from Industrial and Manufacturing Sources

Manufacturing and other industrial products and processes are responsible for a great many of the hazardous occupational and environmental exposures experienced by Americans.  Many of these contaminants— even substances banned more than 30 years ago—remain ubiquitous in the environment because they break down very slowly, if at all.  Other industrial chemicals or processes have hazardous by-products or metabolites.  Numerous chemicals used in manufacturing remain in or on the product as residues, while others are integral components of the products themselves.  Further, in the ongoing quest for more effective and efficient ways of making industrial and consumer products, new chemicals and other substances are being created continually and existing substances are being put to new uses.  Limited research to date on unintended health effects of nanomaterials, for example, suggests that unanticipated environmental hazards may emerge from the push for progress.

Exposure to Contaminants from Agricultural Sources

The entire U.S. population is exposed on a daily basis to numerous agricultural chemicals, some of which also are used in residential and commercial landscaping.  Many of these chemicals have known or suspected carcinogenic or endocrine- disrupting properties.  Pesticides (insecticides, herbicides, and fungicides) approved for use by the U.S. Environmental Protection Agency (EPA) contain nearly 900 active ingredients, many of which are toxic.  Many of the solvents, fillers, and other chemicals listed as inert ingredients on pesticide labels also are toxic, but are not required to be tested for their potential to cause chronic diseases such as cancer.  In addition to pesticides, agricultural fertilizers and veterinary pharmaceuticals are major contributors to water pollution, both directly and as a result of chemical processes that form toxic by-products when these substances enter the water supply.  Farmers and their families, including migrant workers, are at highest risk from agricultural exposures.  Because agricultural chemicals often are applied as mixtures, it has been difficult to clearly distinguish cancer risks associated with individual agents.

Environmental Exposures Related to Modern Lifestyles

Conveniences of modern life—automobile and airplane travel, dry cleaning, potable tap water, electricity, and cellular communications, to name a few—have made daily life easier for virtually all Americans.  Some of these conveniences, however, have come at a considerable price to the environment and human health, and the true health impact of others is unconfirmed.  For example, mobile source air emissions (e.g., from cars, trucks, other passenger vehicles, ships), especially diesel particulate pollution, are responsible for approximately 30 percent of cancer resulting from air pollution. 

Disinfection of public water supplies has dramatically reduced the incidence of waterborne illnesses and related mortality in the United States, but research indicates that long-term exposure to disinfection by-products such as trihalomethanes may increase cancer risk.  Chemicals used for household pest control can become a component of carpet dust, posing a risk to children when they play on the floor.

Sharp controversy exists in the scientific community as to possible adverse health effects from exposure to low frequency electromagnetic energy.  The use of cell phones and other wireless technology is of great concern, particularly since these devices are being used regularly by ever larger and younger segments of the population.  At this time, there is no evidence to support a link between cell phone use and cancer.  However, the research on cancer and other disease risk among long-term and heavy users of contemporary wireless devices is extremely limited.  Similarly, current and potential harms from extremely low frequency radiation are unclear and require further study.  In addition, ultraviolet radiation from excess sun exposure and tanning devices has been proven to substantially increase skin cancer risk.

Exposure to Hazards from  Medical Sources

In the past two decades, improved imaging technologies, nuclear medicine examinations, and new pharmaceutical interventions have made possible significant strides in our ability to diagnose and treat human disease, including cancer.  It is becoming increasingly clear, however, that some of these same technologies and drugs that have contributed so greatly to health status and longevity also carry risks.

While ionizing radiation exposures from radon, occupational, and other sources have remained essentially stable over the past 30 years, Americans now are estimated to receive nearly half of their total radiation exposure from medical imaging and other medical sources, compared with only 15 percent in the early 1980s.  The increase in medical radiation has nearly doubled the total average effective radiation dose per individual in the United States. 

Computed tomography (CT) and nuclear medicine tests alone now contribute 36 percent of the total radiation exposure and 75 percent of the medical radiation exposure of the U.S. population.  Medical imaging of children is of special concern; compared with adults, children have many more years of life during which a malignancy initiated by medical radiation can develop.  Many referring physicians, radiology professionals, and the public are unaware of the radiation dose associated with various tests or the total radiation dose and related increased cancer risk individuals may accumulate over a lifetime.  People who receive multiple scans or other tests that require radiation may accumulate doses equal to or exceeding that of Hiroshima atomic bomb survivors.  It is believed that a single large dose of ionizing radiation and numerous low doses equal to the single large dose have much the same effect on the body over time.

Moreover, radiation dose for the same test can vary dramatically depending on the equipment used, technologist skill, application of dose-reduction strategies, and patient size, age, and gender.  Licensure of imaging and radiation therapy technologists varies depending on the type of test performed by the technologist.  Some states have only partial regulation; six states and the District of Columbia have no licensure or regulatory provisions of any kind.

In addition, pharmaceuticals have become a considerable source of environmental contamination.  Drugs of all types enter the water supply when they are excreted or improperly disposed of; the health impact of long-term exposure to varying mixtures of these compounds is unknown.

Exposure to Contaminants  and Other Hazards from  Military Sources

The military is a major source of toxic occupational and environmental exposures that can increase cancer risk.  Information is available about some military activities that have directly or indirectly exposed military and civilian personnel to carcinogens and contaminated soil and water in numerous locations in the United States and abroad. 

However, we may never know the full extent of environmental contamination from military sources.  Nearly 900 Superfund sites are abandoned military facilities or facilities that produced materials and products for or otherwise supported military needs.  Some of these sites and the areas surrounding them became heavily contaminated due to improper storage and disposal of known or suspected carcinogens including solvents, machining oils, metalworking fluids, and metals.  In some cases, these contaminants have spread far beyond their points of origin because they have been transported by wind currents or have leached into drinking water supplies.

Hundreds of thousands of military personnel and civilians in the United States received significant radiation doses as a result of their participation in nuclear weapons testing and supporting occupations and industries, including nuclear fuel and weapons production, and uranium mining, milling, and ore transport.  Hundreds of thousands more were irradiated at levels sufficient to cause cancer and other diseases.  These populations include the families of military and civilian workers, and people—known as “downwinders”—living or working in communities surrounding or downstream from testing and related activities, and in relatively distant areas to which nuclear fallout or other radioactive material spread. 

Federal responses to the plight of affected individuals have been unsatisfactory.  Those affected lack knowledge about the extent of their exposure or potential health problems they may face.  Similarly, most health care providers are not aware of cancer and other latent radiation effects and therefore are unlikely to adequately monitor patients for these health conditions.  Exposure to ionizing radiation related to nuclear weapons testing is an underappreciated issue worldwide.

Exposure to Environmental Hazards from Natural Sources

Most environmental hazards with the potential to raise cancer risk are the product of human activity, but some environmental carcinogens come from natural sources.  For example, radon gas, which forms naturally from the breakdown of uranium mineral deposits, is the second leading cause of lung cancer in the United States and the leading cause of lung cancer among people who have never smoked.  Radon-induced lung cancer is responsible for an estimated average of 21,000 deaths annually.  People who smoke and also are exposed to radon have a higher risk of lung cancer than from either exposure alone.

Although human activities such as mining, ore processing, use of arsenic-containing
pesticides, and burning of fossil fuels are major contributors to waterborne arsenic in the U.S., most inorganic arsenic in drinking water is from natural sources.  Inorganic arsenic in drinking water has been linked to skin, lung, bladder, and kidney cancer in both sexes and with prostate cancer in men, as well as numerous non-cancerous conditions including endocrine, reproductive, and developmental effects.

Reducing Environmental Cancer Risk: A Call to Action

The burgeoning number and complexity of known or suspected environmental carcinogens compel us to act to protect public health, even though we may lack irrefutable proof of harm.  Action is possible at several levels: conducting scientific research to enhance our understanding and by extension, our ability to prevent and respond to environmental carcinogens; enforcing existing policies and regulations that protect workers and the public; implementing policy and regulatory changes that support public health and reduce the burden of cancer; and taking personal action.

The Panel concludes that:

We Need to Determine the Full Extent of Environmental Influences on Cancer

At this time, we do not know how much environmental exposures influence cancer risk and related immune and endocrine dysfunction.  Environmental contamination varies greatly by type and magnitude across the nation, and the lifetime effects of exposure to combinations of chemicals and other agents are largely unstudied.  Similarly, the cancer impact of exposures during key “windows of vulnerability” such as the prenatal period, early life, and puberty are not well understood.  Nonetheless, while these diverse effects often are difficult to quantify with existing technologies and research methods, in a great many instances, we know enough to act.

The Nation Needs a Comprehensive, Cohesive Policy Agenda Regarding Environmental Contaminants and Protection of Human Health

Environmental health, including cancer risk, has been largely excluded from overall national policy on protecting and improving the health of Americans.  It is more effective to prevent disease than to treat it, but cancer prevention efforts have focused narrowly on smoking, other lifestyle behaviors, and chemopreventive interventions.  Scientific evidence on individual and multiple environmental exposure effects on disease initiation and outcomes, and consequent health system and societal costs, are not being adequately integrated into national policy decisions and strategies for disease prevention, health care access, and health system reform.

Children Are at Special Risk for Cancer Due to Environmental Contaminants and Should Be Protected

Opportunities for eliminating or minimizing cancer-causing and cancer-promoting environmental exposures must be acted upon to protect all Americans, but especially children.  They are at special risk due to their smaller body mass and rapid physical development, both of which magnify their vulnerability to known or suspected carcinogens, including radiation.  Numerous environmental contaminants can cross the placental barrier; to a disturbing extent, babies are born “pre-polluted.” Children also can beharmed by genetic or other damage resulting from environmental exposures sustained by the mother (and in some cases, the father). There is a critical lack of knowledge and appreciation of environmental threats to children’s health and a severe shortage of researchers and clinicians trained in children’s environmental health.

Continued Epidemiologic  and Other Environmental  Cancer Research Is Needed

Available evidence on the level of potential harm and increased cancer risk from many environmental exposures is insufficient or equivocal.  The Panel is particularly concerned that the impact, mechanisms of action, and potential interactions of some known and suspected carcinogens are poorly defined.

Meaningful measurement and assessment of the cancer risk associated with many environmental exposures are hampered by a lack of accurate measurement tools and methodologies.  This is particularly true regarding cumulative exposure to specific established or possible carcinogens, gene-environment interactions, emerging technologies, and the effects of multiple agent exposures.  Single-agent toxicity testing and reliance on animal testing are inadequate to address the backlog of untested chemicals already in use and the plethora of new chemicals introduced every year.  Some high-throughput screening (HTS) technologies are available to enable testing of many chemicals and other contaminants simultaneously, but many remain to be developed to meet chemical testing needs.  Support also is needed to develop methods for interpreting the wealth of data that HTS technologies generate.  At this time, incentives to encourage development of this research are nearly non-existent.

Support for large, longitudinal studies to clarify the nature and magnitude of cancer risk attributable to environmental contaminants must continue.  The capacity to collect biologic samples at the inception of studies is essential; even if current technologies do not allow these samples to be fully utilized at this time, it must be assumed that such technologies will evolve and enable use of collected biosamples to provide essential study baseline data.  Personal health data privacy issues that currently limit research access to data and biosamples will need to be addressed. Cancer risk assessment also is hampered by lack of access to existing exposure data, especially for occupational/industrial exposures, and regarding levels of radon, asbestos, and other contaminants in schools and day care centers.

An Environmental Health Paradigm for Long-Latency Disease Is Needed

Recognizing that results of laboratory and animal studies do not always predict human responses, an environmental health paradigm for long-latency diseases is needed to enable regulatory action based on compelling animal and in vitro evidence before cause and effect in humans has been proven.

Existing Regulations for Environmental Contaminants Need to Be Enforced and Updated; Stronger Regulation Is Needed

Weak laws and regulations, inefficient enforcement, regulatory complexity, and fragmented authority allow avoidable exposures to known or suspected cancer- causing and cancer-promoting agents to continue and proliferate in the workplace and the community.  Existing regulations, and the exposure assessments on which they are based, are outdated in most cases, and many known or suspected carcinogens are completely unregulated.  Enforcement of most existing regulations is poor.  In virtually all cases, regulations fail to take multiple exposures and exposure interactions into account.  In addition, regulations for workplace environments are focused more on safety than on health.

Industry has exploited regulatory weaknesses, such as government’s reactionary (rather than precautionary) approach to regulation.  Likewise, industry has exploited government’s use of an outdated methodology for assessing “attributable fractions” of the cancer burden due to specific environmental exposures.  This methodology has been used effectively by industry to justify introducing untested chemicals into the environment.

Radiation Exposure from Medical Sources Is Underappreciated

The use of radiation-emitting medical tests is growing rapidly.  Efforts are needed to eliminate unnecessary testing and improve both equipment capability and operator skill to ensure that radiation doses are as low as reasonably achievable without sacrificing image or test data quality.  At least one initiative is underway to improve and disseminate radiation reduction strategies and educate physicians, device manufacturers, their training staff, and others about radiation doses associated with specific tests.  No mechanism currently exists to enable individuals to estimate their personal cumulative radiation exposure, which would help patients and physicians weigh the benefits and potential harm of contemplated imaging and nuclear medicine tests.

Medical Professionals Need to Consider Occupational and Environmental Factors When Diagnosing Patient Illness

Physicians and other medical professionals ask infrequently about patient workplace and home environments when taking a medical history.  Such information can be invaluable in discovering underlying causes of disease. 

Moreover, gathering this information would contribute substantially to the body of knowledge on environmental cancer risk. Workers, Other Populations with Known Exposures, and the General Public Require Full Disclosure of Knowledge about Environmental Cancer Risks.

Individuals and communities are not being provided all available information about environmental exposures they have experienced, the cumulative effects of such exposures, and how to minimize harmful exposures.  The disproportionate burden of exposure to known or suspected carcinogens experienced by specific populations (e.g., agricultural and chemical workers and their families, radiation-exposed groups such as uranium mine workers, nuclear industry workers, nuclear test site workers and “downwinders,” residents of cancer “hot spots” or other contaminated areas) has not been fully acknowledged.

The Military Needs to Aggressively Address the Toxic Environmental Exposures It Has Caused

Toxic materials produced for and used by the military have caused widespread air, soil, and water pollution across the United States and beyond our borders, including chemical and radiation contamination in and around current and former military installations, materiel production facilities, and mines. 

These contaminants, many of which may have serious long-term and latent effects including cancer, are a danger both to military personnel and civilians.  Overall, the military has not responded adequately to health problems associated with its operations absent substantial pressure from those affected, advocacy groups, or the media.  Of special concern, the U.S. has not met its obligation to provide for ongoing health needs of the people of the Republic of the Marshall Islands resulting from radiation exposures they received during U.S. nuclear weapons testing in the Pacific from 1946– 1958.

Safer Alternatives to Many Currently Used Chemicals  Are Urgently Needed

The requisite knowledge and technologies exist to develop alternatives to many currently used chemical agents known or believed to cause or promote cancer.  Many chemists require additional training to understand environmental hazards and reformulate products.  Importantly, “green chemistry” alternative products themselves require longitudinal study to ensure that they do not pose unexpected health hazards.

The Panel believes that just as there are many opportunities for harmful environmental exposures, ample opportunities also exist to intervene in, ameliorate, and prevent environmental health hazards.  Governments, industry, the academic and medical communities, and individuals all have untapped power to protect the health of current and future generations of Americans and reduce the national burden of cancer.

arrow_ro.gif - 828 Bytes  Reports

        Annual Report for 2008-2009 New

         Reducing Environmental Cancer Risk, What We Can Do Now

April 2010
For further information on the President’s Cancer Panel
or additional copies of this report, please contact:
Abby B. Sandler, Ph.D.
Executive Secretary
President’s Cancer Panel
6116 Executive Boulevard
Suite 220, MSC 8349
Bethesda, MD  20814-8349
pcp-r [at] mail [dot] nih [dot] gov

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